Development of liquid chromatography/mass spectrometry based screening assay for PfTrxR inhibitors using relative quantitation of intact thioredoxin
Identifieur interne : 000246 ( Main/Exploration ); précédent : 000245; suivant : 000247Development of liquid chromatography/mass spectrometry based screening assay for PfTrxR inhibitors using relative quantitation of intact thioredoxin
Auteurs : Ranjith Munigunti [États-Unis] ; Angela I. Calder N [États-Unis]Source :
- Rapid Communications in Mass Spectrometry [ 0951-4198 ] ; 2012-09-15.
Abstract
Plasmodium falciparum (Pf) thioredoxin reductase (TrxR) catalyzes the reduction of thioredoxin disulfide (Trx–S2) to thioredoxin dithiol (Trx–(SH)2) that is essential for antioxidant defense mechanism and DNA synthesis in the parasite and is a validated drug target for new antimalarial agents.
Url:
DOI: 10.1002/rcm.6316
Affiliations:
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